Courtesy of The Joint Blog
A new study being published in next month’s issue of the journal Biochemical Society Transactions, and published online early by the National Institute of Health, has found that the brain’s endocannabinoid system – which is activated through cannabis use – has neuroprotective and immunomodulatory capabilities, and may lead to the growth of stem cells.
“Activation of cannabinoid receptors suppresses chronic inflammatory responses through the attenuation of pro-inflammatory mediators”, states the study’s abstract. “Moreover, the endocannabinoid system directs cell fate specification of NSCs (neural stem cells) in the CNS (central nervous sytem)”.
According to researchers; “Pharmacological blockade of CB1 and/or CB2 cannabinoid receptors abolish or decrease NSC proliferation, indicating a critical role for both CB1 and CB2 receptors in the proliferation of NSC via IL-1 signalling pathways.”
They conclude; “Thus the endocannabinoid system, which has neuroprotective and immunomodulatory actions mediated by IL-1 signalling cascades in the brain, could assist the process of proliferation and differentiation of embryonic or adult NSCs, and this may be of therapeutic interest in the emerging field of brain repair.